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KMID : 0386520120200020029
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Research Institute of Korean Medicone
2012 Volume.20 No. 2 p.29 ~ p.39
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Effect of CHT in anti-oxidative and anti-inflammatory related factors
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Kim Jin-Woo
Gim Seon-Bin
Oh Jeong-Min
Yun Mi-Young
Lee Ki-Moo
Kim Dong-Hee
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Abstract
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To investigate the clinical aspects of CHT in atopic dermatitis (AD) treatments, the effect of CHT in anti-oxidative and anti-inflammatory cytokines were tested. 100% or higher cell viability was observed in all tested groups from 25 to 200 using Raw 264.7 cells. CHT showed dose-dependent DPPH scavenging activity, with more than 90% scavenging activities at 800 concentrations. CHT showed dose-dependent suppression activity of ROS production, especially at 200 of 37.5%. CHT decreased NO production activity, with significant decrease of 33.2% at 200 . IL-6, MCP-1, TNF- production rate were decreased by approximately 25% when Raw 264.7 cells were treated with LPS and with CHT of 200 . Also, IL- production rate was decreased by 25% at 100 . The results above indicate that CHT significantly reduces the effect of oxidative and inflammatory cytokines. The use of CHT in dermatitis can be widely suggested.
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KEYWORD
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oriental medicine, atopic dermatitis, oxidative damages, inflammation
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